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Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC
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SYSNO ASEP 0352143 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC Author(s) Bahadir, Ö. (TR)
Citoglu, G. S. (TR)
Šmejkal, K. (CZ)
Dall Acqua, S. (IT)
Özbek, H. (TR)
Cvačka, Josef (UOCHB-X) RID, ORCID
Žemlička, M. (CZ)Number of authors 7 Source Title Journal of Ethnopharmacology. - : Elsevier - ISSN 0378-8741
Roč. 131, č. 1 (2010), s. 83-87Number of pages 5 s. Language eng - English Country IE - Ireland Keywords Scorzonera latifolia ; analgesic activity ; triterpenes Subject RIV CC - Organic Chemistry CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000281325500011 DOI 10.1016/j.jep.2010.06.003 Annotation A traditional mastic named yakı sakızı prepared from the roots of Scorzonera latifolia DC. is used as a folk remedy for treatment of pain in Turkish folk medicine. The extract of the S. latifolia roots was prepared and subjected to isolation procedures. Writhing and tail-flick tests were used to determine the antinociceptive activity. The n-hexane fraction of the S. latifolia root methanolic extract showed potent antinociceptiveactivity in both writhing and tail-flick tests. Three compounds were isolated using bioassay-guided chromatographic purification. Isolated compounds were triterpene taraxasteryl myristate, taraxasteryl acetate, and fern-7-en-3-b-one, structures were elucidated by means of MS and NMR techniques. Both taraxasterol derivatives showed promising antinociceptive activity when compared to reference compounds. The root extract and the isolated compounds showed promising antinociceptive activities. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2011
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