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Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia
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SYSNO ASEP 0351994 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia Author(s) Bohuslavová, Romana (BTO-N) RID
Kolář, František (FGU-C) RID, ORCID, SAI
Kuthanová, Lada (BTO-N)
Neckář, Jan (FGU-C) RID, ORCID
Tichopád, Aleš (BTO-N)
Pavlínková, Gabriela (BTO-N) RID, ORCIDSource Title Journal of Applied Physiology. - : American Physiological Society - ISSN 8750-7587
Roč. 109, č. 4 (2010), s. 1195-1202Number of pages 8 s. Language eng - English Country US - United States Keywords Hypoxia inducible factor 1 alpha ; hypoxia ; gene expression profiling Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA301/09/0117 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520701 - BTO-N (2007-2013) AV0Z50110509 - FGU-C (2005-2011) UT WOS 000285344900033 DOI 10.1152/japplphysiol.00366.2010 Annotation Although physiological responses to chronic hypoxia, including pulmonary hypertension and right ventricular hypertrophy, have been well described, the molecular mechanisms involved in cardiopulmonary adaptations are still not fully understood. We hypothesize that adaptive responses to chronic hypoxia are the result of altered transcriptional regulations in the right and left ventricles. Here we report results from the gene expression profiling of adaptive responses in a chronically hypoxic heart. Of 11 analyzed candidate genes, the expression of seven and four genes, respectively, was significantly altered in the right ventricle of hypoxic male and female mice. In the transcriptional profile of the left ventricle, we identified a single expression change in hypoxic males (Vegfa gene). To directly test the role of HIF1, we analyzed the expression profile in Hif1a partially deficient mice exposed to moderate hypoxia Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2011
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