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Wnt2 regulates progenitor proliferation in the developing ventral midbrain
- 1.0351336 - BFÚ 2011 RIV US eng J - Journal Article
Sousa, K.M. - Villaescusa, J.C. - Čajánek, L. - Ondr, J.K. - Castelo-Branco, G. - Hofstra, W. - Bryja, Vítězslav - Palmberg, C. - Bergman, T. - Wainwright, B. - Lang, R.A. - Arenas, E.
Wnt2 regulates progenitor proliferation in the developing ventral midbrain.
Journal of Biological Chemistry. Roč. 285, č. 10 (2010), s. 7246-7253. ISSN 0021-9258. E-ISSN 1083-351X
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : Wnt2 * ventral midbrain * dopaminergic neuron
Subject RIV: BO - Biophysics
Impact factor: 5.328, year: 2010
In this study, we perform the first purification and signaling analysis of Wnt2 and define the function of Wnt2 in ventral midbrain precursor cultures, as well as in Wnt2-null mice in vivo. Collectively, our observations identify Wnt2 as a novel regulator of dopaminergic progenitors and dopaminergic neuron development.
Permanent Link: http://hdl.handle.net/11104/0191111
Number of the records: 1