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Malignant mesothelioma: biology, diagnosis and therapeutic approaches
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SYSNO ASEP 0351303 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Malignant mesothelioma: biology, diagnosis and therapeutic approaches Author(s) Tomasetti, M. (IT)
Amati, M. (IT)
Santarelli, L. (IT)
Alleva, R. (IT)
Neužil, Jiří (UMG-J)Source Title Current Molecular Pharmacology. - : Bentham Science Publishers - ISSN 1874-4672
Roč. 2, č. 2 (2009), s. 190-206Number of pages 17 s. Language eng - English Country AE - United Arab Emirates Keywords malignant mesothelioma ; biology ; diagnosis and therapeutic approaches Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50520514 - UMG-J (2005-2011) DOI 10.2174/1874467210902020190 Annotation Malignant mesothelioma (MM) is an aggressive neoplasm of serosal cavities, which is resistant to conventional therapy, with patient survival from presentation of less than 12 months. MM remains a universally fatal disease of increasing incidence worldwide. Although the main risk factor is asbestos exposure, other factors, Simian virus 40 infection and inheritance of susceptibility genes, likely play a role. Asbestos-related carcinogenic process is primarily based on the interaction between susceptibility (genetic and acquired) and exposure to carcinogenic environmental agents. The long promotion phase observed in MM pathogenesis and the absence of early symptoms both contribute to late diagnosis of the disease. This results in delayed therapeutic intervention of patients, making the outcome of the disease very grim. This review presents recent developments in the pathogenesis, diagnosis and new therapeutic approaches of MM. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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