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Glycosylation protects proteins against free radicals generated from toxic xenobiotics
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SYSNO ASEP 0350771 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Glycosylation protects proteins against free radicals generated from toxic xenobiotics Author(s) Martínek, V. (CZ)
Sklenář, Jan (MBU-M)
Dračínský, Martin (UOCHB-X) RID, ORCID
Šulc, M. (CZ)
Hofbauerová, Kateřina (MBU-M) ORCID
Bezouška, K. (CZ)
Frei, E. (DE)
Stiborová, M. (CZ)Source Title Toxicological Sciences. - : Oxford University Press - ISSN 1096-6080
Roč. 117, č. 2 (2010), s. 359-374Number of pages 16 s. Language eng - English Country US - United States Keywords hrp ; sudan I ; ellipticine Subject RIV EC - Immunology R&D Projects 1M0505 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA303/09/0477 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000282055900012 DOI 10.1093/toxsci/kfq206 Annotation Free radicals generated during peroxidase-catalyzed oxidation of two xenobiotics, carcinogenic Sudan I and an anticancer agent ellipticine, easily attack unmodified proteins but not glycoproteins. A significant inverse correlation between the extent of glycosylation of proteins and the degree of binding of Sudan I or ellipticine radicals to these proteins was observed, whereby the protection only occurs if oligosaccharides are covalently bound to the proteins Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2011
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