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Glycosylation regulates NK cell-mediated effector function through PI3K pathway
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SYSNO ASEP 0350365 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Glycosylation regulates NK cell-mediated effector function through PI3K pathway Author(s) Benson, Veronika (MBU-M) RID, ORCID
Grobárová, Valeria (MBU-M)
Richter, Jan (MBU-M) RID
Fišerová, Anna (MBU-M) RIDSource Title International Immunology - ISSN 0953-8178
Roč. 22, č. 3 (2010), s. 167-177Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords cytotoxic activity ; gene regulation ; glycoconjugate Subject RIV EC - Immunology R&D Projects IAA500200620 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA500200509 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA204/06/0771 GA ČR - Czech Science Foundation (CSF) GD310/08/H077 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000274981300004 DOI 10.1093/intimm/dxp123 Annotation The modulation of glycosyltransferases MGAT3 and MGAT5 by chemically defined synthetic GCGN4C correlated with the improvement of NK cell effector functions and the augmentation of tumor cell sensitivity to NK cell-mediated cytotoxicity. These results demostrate the great potential of the GN4C compound as a NK cell-mediated antitumor response modulator Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2011
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