Ultra-low fouling and functionalizable zwitterionic coatings grafted onto SiO2 via a biomimetic adhesive group for sensing and detection in complex media

0350249 - ÚFE 2011 RIV GB eng J - Journal Article
Brault, N., D. - Gao, Ch. - Xue, H. - Piliarik, Marek - Homola, Jiří - Jiang, S. - Yu, Q.
Ultra-low fouling and functionalizable zwitterionic coatings grafted onto SiO2 via a biomimetic adhesive group for sensing and detection in complex media.
Biosensors and Bioelectronics. Roč. 25, č. 10 (2010), s. 2276-2282. ISSN 0956-5663. E-ISSN 1873-4235
Institutional research plan: CEZ:AV0Z20670512
Keywords : Ultra-low fouling * Zwitterionic * Plasma
Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering
Impact factor: 5.361, year: 2010

There is a need for ultra-low fouling and functionalizable surface coatings which sould be for highly sensitive and label-free detection of target analytes in complex media. In this work, a zwitterionic carboxybetaine methacrylate (CBMA)polymer conjugates containing the adhesive biomimetic moiety, 3,4-dihydroxy-1-phenylalanine (DOPA), is formed on SiO2 substrates. The successful use of the zwitterionic surface coating for detection from complex media indicates its potential for broad range of applications including implantable medical devices, in vivo diagnostics, and nano-scale biosensnors.
Permanent Link: http://hdl.handle.net/11104/0190295