A novel chemo-multienzymatic synthesis of bioactive cyclophellitol and epi-cyclophellitol in both enantiopure forms

Number of the records: 1

1.

SYSNO ASEP	0350230
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	A novel chemo-multienzymatic synthesis of bioactive cyclophellitol and epi-cyclophellitol in both enantiopure forms
Author(s)	D'Antona, N. (IT) Morrone, R. (IT) Bovicelli, P. (IT) Gambera, G. (IT) Kubáč, David (MBU-M)_{RID, ORCID} Martínková, Ludmila (MBU-M)_{RID, ORCID}
Source Title	Tetrahedron Asymmetry. - : Elsevier - ISSN 0957-4166 Roč. 21, č. 20 (2010), s. 2448-2454
Number of pages	7 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	BETA-GLUCOSIDASE INHIBITOR ; FACILE SYNTHESES ; CYCLOPHELLITOL
Subject RIV	CC - Organic Chemistry
R&D Projects	OC09046 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000285231400002
DOI	10.1016/j.tetasy.2010.10.010
Annotation	A new route to synthesize cyclophellitol and epi-cyclophellitol from racemic starting materials in enantiopure forms has been developed. The synthesis involves a multi-enzymatic biotransformation pathway of the novel cyano-cyclitol (1R,4S,5R,6R)/(1S,4R,5S,6S)-4,5,6-trihydroxycyclohex-2-enecarbonitrile by a cooperative use of lipase, nitrile hydratase, and amidase
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2011

Number of the records: 1