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CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases
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SYSNO ASEP 0350071 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases Author(s) Spáčilová, Pavla (UOCHB-X) RID, ORCID
Nauš, Petr (UOCHB-X) RID
Pohl, Radek (UOCHB-X) RID, ORCID
Votruba, Ivan (UOCHB-X) RID
Snášel, Jan (UOCHB-X) RID
Zábranská, Helena (UOCHB-X) RID
Pichová, Iva (UOCHB-X) RID, ORCID
Ameral, R. (US)
Birkuš, G. (US)
Cihlař, T. (US)
Hocek, Michal (UOCHB-X) RID, ORCIDNumber of authors 11 Source Title ChemMedChem. - : Wiley - ISSN 1860-7179
Roč. 5, č. 8 (2010), s. 1386-1396Number of pages 11 s. Language eng - English Country DE - Germany Keywords nucleosides ; pronucleotides ; deazapurines ; cytostatics Subject RIV CC - Organic Chemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000281061300023 DOI 10.1002/cmdc.201000192 Annotation A series of cycloSal-phosphate prodrugs of a recently described new class of nucleoside cytostatics (6-hetaryl-7-deazapurine ribonucleosides) was prepared. The in vitro cytostatic effect of the pronucleotides was compared with parent nucleoside analogues. In most cases, the activity of the pronucleotide was similar to or somewhat lower than that of the corresponding parent nucleosides. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2011
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