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Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use

SYSNO ASEP	0349828
Document Type	P - Patent
R&D Document Type	Patent or other outcome protected by special legislation
Title	Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use
Author(s)	Moravcová, Daniela (UEB-Q) Havlíček, Libor (UEB-Q)_{RID, ORCID} Kryštof, Vladimír (UEB-Q)_{RID, ORCID} Lenobel, René (UEB-Q)_ORCID Binarová, Pavla (UEB-Q)_RID Mlejnek, P. (CZ) Vojtešek, B. (CZ) Uldrijan, S. (CZ) Schmülling, T. (DE) Strnad, Miroslav (UEB-Q)_{RID, ORCID}
Year of issue	2010
Possible third party use of the result	A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence
Royalty requested	A - Poskytovatel licence požaduje licenční poplatek
Patent no. or utility model no. or industrial design no.	EP1475094
Date of the patent acceptance	28.07.2010
Name of the patent owner	Ústav experimentální botaniky AV ČR, v. v. i., Univerzita Palackého v Olomouci
Current use	B - Patent je využíván na základě uzavřené licenční smlouvy mezi vlastníkem a uživatelem
Language	eng - English
Country	DE - Germany
Keywords	disubstituted pyrazolo[4,3-d]pyrimidine ; cancer therapy ; agricultural practice
Subject RIV	FD - Oncology ; Hematology
R&D Projects	GA301/08/1649 GA ČR - Czech Science Foundation (CSF)
	GA522/09/1576 GA ČR - Czech Science Foundation (CSF)
Annotation	This invention relates to new disubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially in cancer therapy and agricultural practice. The compounds are antimitotic, anticancer, herbicidal, fungicidal and insecticidal having improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known. It is an object of this invention to provide 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines.The solution of this object are 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I.
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2011

Number of the records: 1