Anticancer activity of natural cytokinins: A structure-activity relationship study

Voller, Jiří; Zatloukal, Marek; Lenobel, René; Doležal, Karel; Béres, Tibor; Kryštof, Vladimír; Spíchal, Lukáš; Niemann, P.; Džubák, P.; Hajdúch, M.; Strnad, Miroslav

doi:https://dx.doi.org/10.1016/j.phytochem.2010.04.018

Number of the records: 1

Anticancer activity of natural cytokinins: A structure-activity relationship study

1.

SYSNO ASEP	0349823
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Anticancer activity of natural cytokinins: A structure-activity relationship study
Author(s)	Voller, Jiří (UEB-Q)_{RID, ORCID} Zatloukal, Marek (UEB-Q)_ORCID Lenobel, René (UEB-Q)_ORCID Doležal, Karel (UEB-Q)_{RID, ORCID} Béres, Tibor (UEB-Q)_RID Kryštof, Vladimír (UEB-Q)_{RID, ORCID} Spíchal, Lukáš (UEB-Q)_{RID, ORCID} Niemann, P. (DE) Džubák, P. (CZ) Hajdúch, M. (CZ) Strnad, Miroslav (UEB-Q)_{RID, ORCID}
Source Title	Phytochemistry. - : Elsevier - ISSN 0031-9422 Roč. 41, 11-12 (2010), s. 1350-1359
Number of pages	10 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	SAR ; Cytokinins ; Cancer
Subject RIV	FD - Oncology ; Hematology
R&D Projects	GA301/08/1649 GA ČR - Czech Science Foundation (CSF)
	GA206/09/1284 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50380511 - UEB-Q (2005-2011)
UT WOS	000280321000017
DOI	10.1016/j.phytochem.2010.04.018
Annotation	This study presents the first analysis of relationship between chemical structure of cytokinins and their cytotoxic effects against a panel of human cancer cell lines with diverse histopatothological origin. The results confirm the cytotoxic activity of N6-isopentenyladenosine, kinetin riboside, and N6-benzyladenosine and show that the spectrum of cell lines that are sensitive to these compounds is wider than previously reported. The first evidence that the hydroxylated aromatic cytokinins and cis-zeatin riboside have cytotoxic activities is presented. Most cell lines showed greatest sensitivity to ortho-topolin riboside. Cytokinin nucleotides were usually active in a similar concentration range to the corresponding ribosides. However, cytokinin free bases, 2-methylthio derivatives and glucosides showed little or no toxicity. The study shows that structural requirements for cytotoxic activity of cytokinins against human cancer cell lines differ from their activity in plant bioassays.
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2011

Number of the records: 1