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Chronic Treatment with NGF Induces Spontaneous Fluctuations of Intracellular Ca(2+) in Icilin-Sensitive Dorsal Root Ganglion Neurons of the Rat
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SYSNO ASEP 0349380 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Chronic Treatment with NGF Induces Spontaneous Fluctuations of Intracellular Ca(2+) in Icilin-Sensitive Dorsal Root Ganglion Neurons of the Rat Author(s) Kayano, T. (JP)
Kitamura, N. (JP)
Moriya, A. (JP)
Ozaki, Y. (JP)
Dayanithi, Govindan (UEM-P) RID
Shibuya, I. (JP)Source Title Journal of Veterinary Medical Science - ISSN 0916-7250
Roč. 72, č. 12 (2010), s. 1531-1538Number of pages 8 s. Language eng - English Country JP - Japan Keywords capsaicin ; sensory neuron ; TRPA1 Subject RIV FH - Neurology CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000285986700001 EID SCOPUS 78650804185 DOI 10.1292/jvms.10-0196 Annotation These results suggest that neurons expressing both capsaicin- and icilin-sensitive TRP channels are susceptible to NGF and become hyperexcitable and that Ca2+ influx through voltage-gated Ca2+ channels is the major source contributing to the [Ca2+)]i fluctuations. Since such DRG neurons could play a physiological role as nociceptors, the NGF-induced spontaneous activity of DRG neurons may be the underlying mechanism of neuropathic pain Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
Number of the records: 1