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alpha-Tocopheryl succinate promotes selective cell death induced by vitamin K3 in combination with ascorbate
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SYSNO ASEP 0349345 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title alpha-Tocopheryl succinate promotes selective cell death induced by vitamin K3 in combination with ascorbate Author(s) Tomasetti, M. (IT)
Strafella, E. (IT)
Staffolani, S. (IT)
Santarelli, L. (IT)
Neužil, Jiří (BTO-N) RID
Guerrieri, R. (CZ)Source Title British Journal of Cancer. - : Springer - ISSN 0007-0920
Roč. 102, č. 8 (2010), s. 1224-1234Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords Vitamins ; prostate cancer ; cell-death Subject RIV ED - Physiology CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000276663200005 DOI 10.1038/sj.bjc.6605617 Annotation A strategy to reduce the secondary effects of anti-cancer agents is to potentiate the therapeutic effect by their combination. A combination of vitamin K3 (VK3) and ascorbic acid (AA) exhibited an anti-cancer synergistic effect. The redox-silent vitamin E analogue alpha-tocopheryl succinate (alpha-TOS) was used in combination with VK3 and AA to evaluate their effect on prostate cancer cells. These cells were sensitive to alpha-TOS and VK3 treatment, but resistant to AA upto 3.2 mM. When combined, a synergistic effect was found for VK3-AA, whereas alpha-TOS-VK3 and alpha-TOS-AA combination showed an antagonist and additive effect, respectively. However, sub-lethal doses of AA-VK3 combination combined with a sub-toxic dose of alpha-TOS showed to induce cell death resembling autoschizis. Associated with this cell demise, lipid peroxidation, DNA damage, cytoskeleton alteration, lysosomal-mitochondrial perturbation, and release of cytochrome c without caspase activation were observed Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2011
Number of the records: 1