Cytotoxic Activities of Several Geranyl-Substituted Flavanones

Šmejkal, K.; Svačinová, Jana; Šlapetová, T.; Schneiderová, K.; Dall’Acqua, S.; Innocenti, G.; Závalová, V.; Kollár, P.; Chudík, S.; Marek, R.; Julínek, O.; Urbanová, M.; Kartal, M.; Csöllei, M.; Doležal, Karel

doi:https://dx.doi.org/10.1021/np900681y

Number of the records: 1

Cytotoxic Activities of Several Geranyl-Substituted Flavanones

1.

SYSNO ASEP	0349184
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Cytotoxic Activities of Several Geranyl-Substituted Flavanones
Author(s)	Šmejkal, K. (CZ) Svačinová, Jana (UEB-Q) Šlapetová, T. (CZ) Schneiderová, K. (CZ) Dall’Acqua, S. (IT) Innocenti, G. (IT) Závalová, V. (CZ) Kollár, P. (SK) Chudík, S. (CZ) Marek, R. (CZ) Julínek, O. (CZ) Urbanová, M. (CZ) Kartal, M. (HU) Csöllei, M. (HU) Doležal, Karel (UEB-Q)_{RID, ORCID}
Source Title	Journal of Natural Products. - : American Chemical Society - ISSN 0163-3864 Roč. 73, č. 4 (2010), s. 568-572
Number of pages	5 s.
Language	eng - English
Country	US - United States
Keywords	flavanones ; geranyl ; cytotoxicity
Subject RIV	BO - Biophysics
R&D Projects	LC06030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GD522/08/H003 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50380511 - UEB-Q (2005-2011)
UT WOS	000276950000011
DOI	10.1021/np900681y
Annotation	Nine geranylated flavanones isolatér from the fruits of Paulownia tomentosa and two from the roots of Morus alba were examinated for cytotoxicity to selected human cancor cell lines and normal human fibroblasts. Cytotoxicity was determined in vitro using a calcein AM cytotoxicity assay. Cytotoxicity for the THP-1 monocytic leukemia cell line was tested using erythrosin B cell staining. The geranylated compounds tested were compared with the known simple flavanone standards taxifolin (1), naringenin (2), and hesperetin (3), and with the standard anticancer druha olomoucine II, diaziquone and oxaliplatin and antineoplastic compound camptothecin, and showed different levels of cytotoxicity. The effect of structural changes on cytotoxic aktivity, including geranyl substitution of the flavanone skeleton and the oxidation pattern of ring B of the flavanones, are discussed.
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2011

Number of the records: 1