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Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy
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SYSNO ASEP 0348858 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy Author(s) Lammers, T. (DE)
Šubr, Vladimír (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RID
Peschke, P. (DE)
Huber, P. E. (DE)
Hennink, W. E. (NL)
Storm, G. (NL)
Kiessling, F. (DE)Source Title Advanced Engineering Materials. - : Wiley - ISSN 1438-1656
Roč. 12, č. 9 (2010), B413-B421Number of pages 9 s. Language eng - English Country DE - Germany Keywords HPMA copolymers ; targeting ; tumor targeting Subject RIV EI - Biotechnology ; Bionics R&D Projects 1M0505 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000283996400005 DOI 10.1002/adem.200980046 Annotation Using HPMA copolymers as a model drug carrier, and doxorubicin and gemcitabine as model drugs, we here show that long-circulating and passively tumor-targeted polymeric drug carriers interact synergistically with radiotherapy, with radiotherapy improving the tumor accumulation of the copolymers, and with the copolymers improving both the efficacy and the toxicity of radiochemotherapy. These findings indicate that “carrier-based radiochemotherapy” holds significant potential for improving the treatment of advanced solid malignancies. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2011
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