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Copper-catalyzed activation of disulfides as a key step in the synthesis of benzothiazole moieties
- 1.0348739 - ÚOCHB 2011 RIV DE eng J - Journal Article
Hývl, Jakub - Šrogl, Jiří
Copper-catalyzed activation of disulfides as a key step in the synthesis of benzothiazole moieties.
European Journal of Organic Chemistry. -, č. 15 (2010), s. 2849-2851. ISSN 1434-193X. E-ISSN 1099-0690
R&D Projects: GA ČR GA203/08/1318
Institutional research plan: CEZ:AV0Z40550506
Keywords : oxidation * copper * benzothiazole synthesis
Subject RIV: CC - Organic Chemistry
Impact factor: 3.206, year: 2010
A convenient synthesis of substituted benzothiazoles has been accomplished by way of a copper catalyzed reaction of aromatic disulfide amines and aldehydes. The process, which involves copper catalyzed activation of disulfide functionality, proceeds in a tandem fashion via C–H bond activation, followed by aerobic oxidation of a resulting dihydrobenzothiazole intermediate. The scope and limitations of the reaction are demonstrated on a variety of substrates.
Permanent Link: http://hdl.handle.net/11104/0189178
Number of the records: 1