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Depletion of calcium stores contributes to progesterone-induced attenuation of calcium signaling of G protein-coupled receptors
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SYSNO ASEP 0347353 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Depletion of calcium stores contributes to progesterone-induced attenuation of calcium signaling of G protein-coupled receptors Author(s) Gehrig-Burger, K. (DE)
Slaninová, Jiřina (UOCHB-X)
Gimpl, G. (DE)Number of authors 3 Source Title Cellular and Molecular Life Sciences - ISSN 1420-682X
Roč. 67, č. 16 (2010), s. 2815-2824Number of pages 10 s. Language eng - English Country CH - Switzerland Keywords non-genomic effect ; oxytocin ; bradykinin ; progesterone Subject RIV CC - Organic Chemistry CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000280564600009 DOI 10.1007/s00018-010-0360-4 Annotation We demonstrated that within minutes, progesterone inhibits oxytocin- and bradykinin-induced contractions of rat uteri, calcium responses induced by platelet-activating factor in the human endometrial cell line MFE-280, and oxytocin-induced calcium signals in PHM1-31 immortalized pregnant human myometrial cells. Our data indicate that progesterone rapidly depletes intracellular calcium stores. The resulting desensitization of the cells might contribute to the quiescence of the uterus during pregnancy. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2011
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