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Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells
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SYSNO ASEP 0347290 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells Author(s) Fialová, Anna (BC-A)
Cimburek, Zdeněk (MBU-M)
Iezzi, G. (CH)
Kopecký, Jan (BC-A) RIDSource Title Microbes and Infection. - : Elsevier - ISSN 1286-4579
Roč. 12, č. 7 (2010), s. 580-585Number of pages 6 s. Language eng - English Country NL - Netherlands Keywords Tick-borne encephalitis virus ; Dendritic cell ; Tick saliva ; Ixodes ricinus Subject RIV EC - Immunology R&D Projects IAA600960811 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) AV0Z50200510 - MBU-M (2005-2011) UT WOS 000279561500010 DOI 10.1016/j.micinf.2010.03.015 Annotation Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-alpha and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2011
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