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Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells
- 1.0347290 - BC 2011 RIV NL eng J - Journal Article
Fialová, Anna - Cimburek, Zdeněk - Iezzi, G. - Kopecký, Jan
Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells.
Microbes and Infection. Roč. 12, č. 7 (2010), s. 580-585. ISSN 1286-4579. E-ISSN 1769-714X
R&D Projects: GA AV ČR IAA600960811
Institutional research plan: CEZ:AV0Z60220518; CEZ:AV0Z50200510
Keywords : Tick-borne encephalitis virus * Dendritic cell * Tick saliva * Ixodes ricinus
Subject RIV: EC - Immunology
Impact factor: 2.726, year: 2010
Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-alpha and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host.
Permanent Link: http://hdl.handle.net/11104/0188097
Number of the records: 1