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Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand
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SYSNO ASEP 0347184 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand Author(s) Kašpárková, Jana (BFU-R) RID, ORCID
Suchánková, T. (CZ)
Halámiková, Anna (BFU-R)
Zerzánková, Lenka (BFU-R)
Vrána, Oldřich (BFU-R) RID
Margiotta, N. (IT)
Natile, G. (IT)
Brabec, Viktor (BFU-R) RID, ORCIDNumber of authors 8 Source Title Biochemical Pharmacology. - : Elsevier - ISSN 0006-2952
Roč. 79, č. 4 (2010), s. 552-564Number of pages 13 s. Language eng - English Country US - United States Keywords DNA ; platinum ; cancer Subject RIV BO - Biophysics R&D Projects LC06030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ME08017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) OC08003 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1QS500040581 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA400040803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GD301/09/H004 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000273624600004 DOI 10.1016/j.bcp.2009.09.019 Annotation This work describes a mechanistic study aimed at finding differences in those features of mechansim of activity of new antitumor PtII complex [PtCl2(cis-1,4-DACH)] (DACH = diaminocyclohexane) which are associated with its different biological effects in comparison with conventional cisplatin. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2011
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