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The role of miRNAs and endogenous siRNAs in maternal-to-zygotic reprogramming and the establishment of pluripotency
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SYSNO ASEP 0346834 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The role of miRNAs and endogenous siRNAs in maternal-to-zygotic reprogramming and the establishment of pluripotency Author(s) Svoboda, Petr (UMG-J) RID
Flemr, Matyáš (UMG-J)Source Title Embo Reports - ISSN 1469-221X
Roč. 11, č. 8 (2010), s. 590-597Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords RNAi ; miRNA ; pluripotency Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA204/09/0085 GA ČR - Czech Science Foundation (CSF) GAP305/10/2215 GA ČR - Czech Science Foundation (CSF) ME09039 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000280313400011 DOI 10.1038/embor.2010.102 Annotation A review article discussing roles of RNA silencing in establishment and maintenance of pluripotency. A significant part of the transition of an oocyte into pluripotent cells of the embryo occurs in the absence of transcription. Therefore, post-transcriptional mechanisms (including RNA silencing) are important for proper reprogramming and establishment of pluripotency. The article is summarizing current data and is discussing possible roles of RNA silencing in establishment and maintenance of pluripotency. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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