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Cathepsins B1 and B2 in the neuropathogenic schistosome Trichobilharzia regenti: distinct gene expression profiles and presumptive roles throughout the life cycle
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SYSNO ASEP 0346460 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cathepsins B1 and B2 in the neuropathogenic schistosome Trichobilharzia regenti: distinct gene expression profiles and presumptive roles throughout the life cycle Author(s) Dolečková, K. (CZ)
Albrecht, Tomáš (UBO-W) RID, SAI, ORCID
Mikeš, L. (CZ)
Horák, P. (CZ)Number of authors 4 Source Title Parasitology Research. - : Springer - ISSN 0932-0113
Roč. 107, č. 3 (2010), s. 751-755Number of pages 5 s. Language eng - English Country DE - Germany Keywords Cathepsin ; Schistosome ; Trichobilharzia ; Helminth ; Neuropathogen Subject RIV GJ - Animal Vermins ; Diseases, Veterinary Medicine R&D Projects LC06073 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60930519 - UBO-W (2005-2011) UT WOS 000280562900035 EID SCOPUS 77955468898 DOI 10.1007/s00436-010-1943-6 Annotation Real-time polymerase chain reaction was used to characterize the temporal distribution of transcripts of two cathepsins in different developmental stages of Trichobilharzia regenti: cathepsin B1 originally described from the gut lumen of schistosomula with presumptive role in nutrient digestion and cathepsin B2 originally found in penetration glands of cercariae with probable involvement in invasion of the final host. The mRNA expression profiles clearly show distinct expression of cathepsins B1 and B2 during the development from eggs to cercariae. In the case of both cathepsins, the highest level of transcription was detected in intravertebrate stages. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2011
Number of the records: 1