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Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy
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SYSNO ASEP 0345886 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy Author(s) Keough, D. T. (AU)
Hocková, Dana (UOCHB-X) RID, ORCID
Krečmerová, Marcela (UOCHB-X) RID, ORCID
Česnek, Michal (UOCHB-X) RID, ORCID
Holý, Antonín (UOCHB-X)
Naesens, L. (BE)
Brereton, I. M. (AU)
Winzor, D. J. (AU)
de Jersey, J. (AU)
Guddat, L. W. (AU)Number of authors 10 Source Title Molecular and Biochemical Parasitology. - : Elsevier - ISSN 0166-6851
Roč. 173, č. 2 (2010), s. 165-169Number of pages 5 s. Language eng - English Country NL - Netherlands Keywords acyclic nucleoside phosphonates ; Plasmodium vivax ; 6-oxopurine phosphoribosyltransferase Subject RIV CC - Organic Chemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000280659300015 DOI 10.1016/j.molbiopara.2010.05.018 Annotation For protozoan parasites, 6-oxopurine phosphoribosyltransferases (PRTases) provide the only metabolic pathway to synthesize the purine nucleoside monophosphates essential for DNA/RNA production. This enzyme from Plasmodium vivax was cloned, expressed and purified and its properties compared with those of the corresponding enzymes from human and P. falciparum. Several acyclic nucleoside phosphonates were evaluated as inhibitors of PvHGPRT giving Ki values as low as 0.5 .mu.M. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2011
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