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Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
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SYSNO ASEP 0345709 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Animals lacking link protein have attenuated perineuronal nets and persistent plasticity Author(s) Carulli, D. (GB)
Pizzorusso, T. (IT)
Kwok, J. C. F. (GB)
Putignano, E. (IT)
Poli, A. (IT)
Forostyak, Serhiy (UEM-P) RID, ORCID
Andrews, M. R. (GB)
Deepa, S. S. (GB)
Glant, T. (US)
Fawcett, J. W. (GB)Source Title Brain - ISSN 0006-8950
Roč. 133, č. 8 (2010), s. 2331-2347Number of pages 17 s. Language eng - English Country GB - United Kingdom Keywords plasticity ; ocular dominance ; extracellular matrix Subject RIV FH - Neurology CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000280982700015 DOI 10.1093/brain/awq145 Annotation Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult central nervous system and their digestion with chondroitinase reactivates plasticity. In this article has been measured the changes in the CSPGs that occur during the critical period in rats and mice. The molecular event that triggers PNN formation has been identified, showing that the PNN component cartilage link protein Crtl1 (Hapln1) is up-regulated as the structures form. In keeping with the hypothesis that PNN maturation down-regulates plasticity, we found that adult plasticity in the visual and somatosensory systems of mice lacking Crtl1 was strongly enhanced. Overall, our findings demonstrate that the formation of PNNs triggered by neuronal Crtl1 synthesis is a key event in the diminuation of plasticity in the adult CNS and suggest that modification of PNNs is how CSPGs reactivate plasticity. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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