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Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase
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SYSNO ASEP 0345303 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase Author(s) Ondroušková, E. (CZ)
Slováčková, J. (CZ)
Pelková, V. (CZ)
Procházková, Jiřina (BFU-R) RID, ORCID
Souček, Karel (BFU-R) RID, ORCID
Beneš, P. (CZ)
Šmarda, J. (CZ)Number of authors 7 Source Title Biological Chemistry. - : Walter de Gruyter - ISSN 1431-6730
Roč. 390, č. 1 (2009), s. 49-58Number of pages 10 s. Language eng - English Country DE - Germany Keywords Bcl-2 ; heavy metals ; Jun N-terminal kinase Subject RIV BO - Biophysics R&D Projects GA204/07/0834 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000263247800008 DOI 10.1515/BC.2009.007 Annotation This study shows that phosphorylation of Bcl-2 can be induced by heavy metals due to activation of the Jun N-terminal kinase pathway that is not linked to the G2/M cell cycle arrest. Furthermore, we demonstrate that hyperphosphorylated Bcl-2 protein is a more potent inhibitor of zinc-induced cell death than its hypophosphorylated mutant form. These data suggest that regulation of Bcl-2 protein function by phosphorylation is an important part of cell responses to stress. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2011
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