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Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat
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SYSNO ASEP 0344049 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat Author(s) Jirout, M. L. (US)
Friese, R. S. (US)
Mahapatra, N. R. (US)
Mahata, M. (US)
Taupenot, L. (US)
Mahata, S. K. (US)
Křen, V. (CZ)
Zídek, Václav (FGU-C) RID
Fischer, J. (DE)
Maatz, H. (DE)
Ziegler, M. G. (US)
Pravenec, Michal (FGU-C) RID, ORCID
Hubner, N. (DE)
Aitman, T. J. (GB)
Schork, N. J. (US)
O´Connor, D. T. (US)Source Title Human Molecular Genetics. - : Oxford University Press - ISSN 0964-6906
Roč. 19, č. 13 (2010), s. 2567-2580Number of pages 14 s. Language eng - English Country GB - United Kingdom Keywords spontaneously hypertensive rat ; catecholamines ; blood pressure Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA500110604 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000279674200003 DOI 10.1093/hmg/ddq135 Annotation We identified cis-acting eQTLs for Dbh, Pnmt (catecholamine biosynthesis) and Vamp1 (catecholamine secretion); enzymatic activities of Dbh and Pnmt paralleled transcripts, with pQTLs for activities mirroring eQTLs. We also detected trans-regulated expression of Vmat1 and Chga (both involved in catecholamine storage), with co-localization of these trans-eQTLs to the Pnmt locus. The finding of such cis- and trans-QTLs at an age before the onset of frank hypertension suggests that these heritable changes in biosynthetic enzyme expression represent primary genetic mechanisms for regulation of catecholamine action and blood pressure control in this widely studied model of hypertension Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2011
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