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Channel character of uncoupling protein-mediated transport
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SYSNO ASEP 0344047 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Channel character of uncoupling protein-mediated transport Author(s) Ježek, Petr (FGU-C) RID, ORCID
Jabůrek, Martin (FGU-C) ORCID, RID
Garlid, K. D. (US)Source Title FEBS Letters. - : Wiley - ISSN 0014-5793
Roč. 584, č. 10 (2010), s. 2135-2141Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords mitochondrial uncoupling protein ; anion uniport ; eyring barrier model Subject RIV BO - Biophysics R&D Projects GA303/07/0105 GA ČR - Czech Science Foundation (CSF) ME09018 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000277409600027 DOI 10.1016/j.febslet.2010.02.068 Annotation An existence of pure proton channel in UCPs is excluded by the equivalent flux-voltage dependencies for uniport of FAs and halide anions, which are best described by the Eyring barrier variant with a single energy well in the middle of two peaks. We suggest that UCPs took advantage of the common FA-uncoupling function of SLC25 family carriers and dropped their solute transport function Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2011
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