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Para-hydrogenated Glucose Derivatives as Potential 13C-Hyperpolarized Probes for Magnetic Resonance Imaging
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SYSNO ASEP 0343958 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Para-hydrogenated Glucose Derivatives as Potential 13C-Hyperpolarized Probes for Magnetic Resonance Imaging Author(s) Reineri, F. (IT)
Santelia, D. (IT)
Viale, A. (IT)
Cerutti, E. (IT)
Poggi, L. (IT)
Tichý, Tomáš (UOCHB-X) RID
Premkumar, S. S. D. (IT)
Gobetto, R. (IT)
Aime, S. (IT)Number of authors 9 Source Title Journal of the American Chemical Society. - : American Chemical Society - ISSN 0002-7863
Roč. 132, č. 20 (2010), s. 7186-7193Number of pages 8 s. Language eng - English Country US - United States Keywords magnetic resonance imaging ; para-hydrogen-induced polarization ; glucose Subject RIV CC - Organic Chemistry CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000277999700058 DOI 10.1021/ja101399q Annotation A set of molecules in which a glucose moiety is bound to a hydrogenable synthon has been synthesized and evaluated for hydrogenation reactions and for the corresponding PHIP effects, in order to select suitable candidates for an in vivo MRI method for the assessment of glucose cellular uptake. It has been found that amidic derivatives do not yield any polarization enhancement. In contrast, ester derivatives are hydrogenated in high yield and afford enhanced 1H and 13C NMR spectra after para-hydrogenation. These molecules may find interesting applications in 13C MRI as hyperpolarized probes for assessing the activity of glucose transporters in cells. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2011
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