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The reduction of doxorubicin at a mercury electrode and monitoring its interaction with DNA using constant current chronopotentiometry
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SYSNO ASEP 0343810 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The reduction of doxorubicin at a mercury electrode and monitoring its interaction with DNA using constant current chronopotentiometry Author(s) Vacek, J. (CZ)
Havran, Luděk (BFU-R) RID, ORCID
Fojta, Miroslav (BFU-R) RID, ORCIDNumber of authors 3 Source Title Collection of Czechoslovak Chemical Communications. - : Ústav organické chemie a biochemie AV ČR, v. v. i. - ISSN 0010-0765
Roč. 74, 11-12 (2009), s. 1727-1738Number of pages 12 s. Language eng - English Country CZ - Czech Republic Keywords doxorubicin ; mercury electrode ; chronopotentiometry Subject RIV BO - Biophysics R&D Projects GA203/07/1195 GA ČR - Czech Science Foundation (CSF) LC06035 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1QS500040581 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000274667900012 DOI 10.1135/cccc2009512 Annotation Voltammetry with linear scan and chronopotentiometric stripping (CPS) with constant current were used for the analysis of doxorubicin (DOX) at the hanging mercury drop electrode. CPS was used for the study of DOX in situ electrochemical reduction in adsorbed state and for ex situ (adsorptive transfer) analysis of the drug. The CPS method was also applied to monitor the DOX interaction with double- and single-stranded DNA. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2011
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