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Nucleotide variability of Ťahyňa virus (Bunyaviridae, Orthobunyavirus) small (S) and medium (M) genomic segments in field strains differing in biological properties
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SYSNO ASEP 0342878 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nucleotide variability of Ťahyňa virus (Bunyaviridae, Orthobunyavirus) small (S) and medium (M) genomic segments in field strains differing in biological properties Author(s) Kilian, P. (CZ)
Růžek, Daniel (BC-A) RID, ORCID
Danielová, V. (CZ)
Hypša, Václav (BC-A) RID
Grubhoffer, Libor (BC-A) RID, ORCIDSource Title Virus Research. - : Elsevier - ISSN 0168-1702
Roč. 149, č. 1 (2010), s. 119-123Number of pages 5 s. Language eng - English Country NL - Netherlands Keywords Tahyna virus ; Bunyavirus ; california group ; genetic variability ; virulence Subject RIV EB - Genetics ; Molecular Biology R&D Projects LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000276341900017 DOI 10.1016/j.virusres.2010.01.005 Annotation Tahyna virus (TAHV), a mosquito-borne bunyavirus (California group), is frequently associated with inapparent or influenza-like (Valtice fever) infections in humans. Field TAHV strains exhibit a high variability in their biological properties with respect to virulence for laboratory mouse, temperature-sensitivity or character of plaques in cell culture. We analyzed complete nucleotide sequences of the small (S) and medium (M) genomic segments of field TAHV strains with different combinations of phenotypic markers. S segment was highly conservative in all analyzed TAHV strains. Within the M segment, the highest variability was observed in the G(C) gene encoding viral envelope protein and to a less extent also in the NSm gene. However, 5' and 3' non-coding regions of M segment, as well as in G(N) gene exhibited highly conservative pattern, indicating its functional importance, but minor or no role in the determination of biological properties of TAHV field strains. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2011
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