Number of the records: 1
Estradiol Supplementation Helps Overcome Central Leptin Resistance of Ovariectomized Mice on a High Fat Diet
- 1.
SYSNO ASEP 0342535 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Estradiol Supplementation Helps Overcome Central Leptin Resistance of Ovariectomized Mice on a High Fat Diet Author(s) Matyšková, Resha (UOCHB-X)
Železná, Blanka (UOCHB-X) RID, ORCID
Maixnerová, Jana (UOCHB-X)
Koutová, Darja (UOCHB-X)
Haluzík, M. (CZ)
Maletínská, Lenka (UOCHB-X) RID, ORCIDNumber of authors 6 Source Title Hormone and Metabolic Research - ISSN 0018-5043
Roč. 42, č. 3 (2010), s. 182-186Number of pages 5 s. Language eng - English Country DE - Germany Keywords leptin ; estrogen deficiency ; obesity Subject RIV CE - Biochemistry R&D Projects GA305/06/0427 GA ČR - Czech Science Foundation (CSF) GA303/09/0744 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000275500600005 DOI 10.1055/s-0029-1243250 Annotation Ovariectomized mice on a high fat diet represent a model of diet-induced obesity during estrogen deficiency. Ovariectomized mice on a high fat diet developed extreme obesity and hyperleptinemia and moderate hyperinsulinemia compared to those on a standard diet. The response to centrally injected leptin in ovariectomized mice on a high fat diet was insignificant, whereas in 17beta-estradiol-3-benzoate-supplemented mice, the effect was significant, particularly with respect to body weight. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2011
Number of the records: 1