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Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid
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SYSNO ASEP 0341983 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid Author(s) Folbergrová, Jaroslava (FGU-C) RID
Ješina, Pavel (FGU-C)
Haugvicová, Renata (FGU-C)
Lisý, Václav (FGU-C)
Houštěk, Josef (FGU-C) RID, ORCIDSource Title Neurochemistry International. - : Elsevier - ISSN 0197-0186
Roč. 56, č. 3 (2010), s. 394-403Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords homocysteic acid-induced seizures ; mitochondrial complex I activity ; persisting decrease Subject RIV FH - Neurology R&D Projects GA309/05/2015 GA ČR - Czech Science Foundation (CSF) GA309/08/0292 GA ČR - Czech Science Foundation (CSF) 1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000275949000004 DOI 10.1016/j.neuint.2009.11.011 Annotation A marked decrease (cca60 %) of mitochondrial complex I activity (observed during the acute phase of seizures induced in immature rats by homocysteic acid) persists during long periods of survival (up to 5 weeks) following seizures. It is accompanied by significant increase of three mitochondrial markers of oxidative damage. The decrease of complex I activity was substantially reduced by treatment with selected free radical scavengers Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2011
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