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Measuring diffusion parameters in the brain: comparing the real-time iontophoretic method and diffusion-weighted magnetic resonance
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SYSNO ASEP 0341670 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Measuring diffusion parameters in the brain: comparing the real-time iontophoretic method and diffusion-weighted magnetic resonance Title Měření difúních parametrů v mozku: porovnání iontoforetické metody v reálném čase a difúzně vážené magnetické rezonance Author(s) Voříšek, Ivan (UEM-P)
Syková, Eva (UEM-P) RIDSource Title Acta Physiologica. - : Wiley - ISSN 1748-1708
Roč. 195, č. 1 (2009), s. 101-110Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords Apparent diffusion coefficient ; Diffusion anisotropy ; Extracellular matrix Subject RIV FH - Neurology R&D Projects LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000261636700011 DOI 10.1111/j.1748-1716.2008.01924.x Annotation The extracellular space (ECS) diffusion parameters influence the movement of ions, neuroactive substances, hormones and metabolites in the nervous tissue. They also affect extrasynaptic transmission, a mode of signal transmission dependent solely on diffusion. This review compares in detail two methods for studying diffusion in the brain: the real-time iontophoretic tetramethylammonium method for ECS volume fraction and tortuosity measurements and diffusion weighted-magnetic resonance imaging for measuring the apparent diffusion coefficient of water. The results obtained using both methods under physiological conditions (post-natal development, ageing) or in pathologies (brain injury, ischaemia) and their similarities and differences are discussed. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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