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Acute and chronic effects of antidepressants on the G-protein alpha subunit profiles in vitro and in vivo
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SYSNO ASEP 0341172 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Acute and chronic effects of antidepressants on the G-protein alpha subunit profiles in vitro and in vivo Author(s) Páv, M. (CZ)
Kovářů, František (UZFG-Y)
Lisá, Věra (FGU-C)
Ondráčková-Zeleničková, P. (CZ)
Fišerová, Anna (MBU-M) RID
Kovářu, H. (CZ)Source Title Neuroendocrinology Letters - ISSN 0172-780X
Roč. 30, č. 5 (2009), s. 592-598Number of pages 7 s. Language eng - English Country SE - Sweden Keywords C6 glioma cells ; C6 astrocytoma cell line ; antidepressant Subject RIV ED - Physiology R&D Projects IAA601680801 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50450515 - UZFG-Y (2005-2011) AV0Z50110509 - FGU-C (2005-2011) AV0Z50200510 - MBU-M (2005-2011) UT WOS 000275266300007 Annotation Neurochemical studies on the etiopathogenesis of depression are also focusing on the transduction system beyond receptors. Trimeric G-proteins play a crucial role in the transmembrane signalling, signal amplification and intracellular processing. Abnormalities of G-protein levels are observed in subjects with depression, G-protein modulation is considered to play a role in the antidepressant mode of action. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2010
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