Number of the records: 1
Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells
- 1.
SYSNO ASEP 0340896 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells Author(s) Maioli, E. (IT)
Greci, L. (IT)
Souček, Karel (BFU-R) RID, ORCID
Hýžďalová, Martina (BFU-R) RID, ORCID
Pecorelli, A. (IT)
Fortino, V. (IT)
Valacchi, G. (IT)Number of authors 7 Source Title Journal of Biomedicine and Biotechnology - ISSN 1110-7243
-, - (2009), s. 1-7Number of pages 7 s. Language eng - English Country US - United States Keywords Rottlerin ; NFkappaB ; HT-29 cells Subject RIV BO - Biophysics R&D Projects GA204/07/0834 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000274891700001 DOI 10.1155/2009/742936 Annotation Rottlerin, a polyphenol isolated from Mallotus Philippinensis, has been recently used as a selective inhibitor of PKC delta, although it can inhibit many kinases and has several biological effects. The current study confirms the antioxidant property of Rottlerin against the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) in vitro and against oxidative stress induced by H(2)O(2) and by menadione in culture cells. We also demonstrate that Rottlerin prevents TNFalpha-dependent NFkappaB activation in MCF-7 cells and in HT-29 cells transfected with the NFkappaB-driven plasmid pBIIX-LUC, suggesting that Rottlerin can inhibit NFkappaB via several pathways and in several cell types. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2010
Number of the records: 1