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No-cGMP Signaling in the Spinal Cord and Brain Stem Circuitry
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SYSNO ASEP 0340868 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Nitric oxide: A regulator of stem cell proliferation and differentiation Author(s) Čížková, D. (SK)
Rosocha, J. (SK)
Vanický, I. (SK)
Jergová, S. (SK)
Nagyová, M. (SK)
Juhásová, Jana (UZFG-Y) RID, ORCID
Čížek, M. (SK)Number of authors 7 Source Title No-cGMP Signaling in the Spinal Cord and Brain Stem Circuitry. - Kerala : Transworld Research Network, 2009 / Lukáčová Nadežda - ISBN 978-81-7895-416-5 Pages s. 27-39 Number of pages 12 s. Number of copy 200 Number of pages 161 Language eng - English Country IN - India Keywords stem cells ; nitric oxide Subject RIV FH - Neurology CEZ AV0Z50450515 - UZFG-Y (2005-2011) Annotation In recent years, cell replacement strategies,together with endogenous stem cell stimulation within the adult central nervous system, has been considered as a promising therapeutic approach to compensate for destroyed neural pools following various neurological disorders. Therefore, a great deal of effort has been going towards establishing the factors which control cellular survival, proliferation and differentiation. Nitric oxide (NO), a diffusible intracellular, intercellular messenger and powerful mediator in the inflammatory cascade in the mammalian nervous system, has been shown to affect embryonic as well as adult neurogenesis. It has been confirmed by several groups that at physiological concentrations NO derived from the neuronal isoform of NO synthase (nNOS) in nitrergic neurons is a negative regulator of stem/progenitor cell pool proliferation and is most likely needed for initiation of differentiation. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2012
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