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Antioxidant and antiviral activities of silybin fatty acid conjugates
- 1.0340841 - MBÚ 2011 RIV FR eng J - Journal Article
Gažák, Radek - Purchartová, Kateřina - Marhol, Petr - Živná, L. - Sedmera, Petr - Valentová, K. - Kato, N. - Matsumura, H. - Kaihatsu, K. - Křen, Vladimír
Antioxidant and antiviral activities of silybin fatty acid conjugates.
European Journal of Medicinal Chemistry. Roč. 45, č. 3 (2010), s. 1059-1067. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA AV ČR KJB400200701; GA MŠMT OC08049; GA MŠMT(CZ) LC06010
Institutional research plan: CEZ:AV0Z50200510
Keywords : Influenza virus * silibinin * silybin
Subject RIV: CC - Organic Chemistry
Impact factor: 3.193, year: 2010
wo selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety
Permanent Link: http://hdl.handle.net/11104/0184002
Number of the records: 1