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Oxidative damage by carcinogenic polycyclic aromatic hydrocarbons and organic extracts from urban air particulate matter
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SYSNO ASEP 0340206 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Oxidative damage by carcinogenic polycyclic aromatic hydrocarbons and organic extracts from urban air particulate matter Author(s) Hanzalová, Kateřina (UEM-P)
Rössner ml., Pavel (UEM-P) RID, ORCID
Šrám, Radim (UEM-P) RIDSource Title Mutation Research - Genetic Toxicology and Environmental Mutagenesis. - : Elsevier - ISSN 1383-5718
Roč. 696, č. 2 (2010), s. 114-121Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords carcinogenic polycyclic aromatic hydrocarbons ; oxidative damage in vitro ; extractable organic matter Subject RIV DN - Health Impact of the Environment Quality R&D Projects 2B08005 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) SP/1B3/8/08 GA MŽP - Ministry of Environment (MŽP) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000276212500005 EID SCOPUS 77549083198 DOI 10.1016/j.mrgentox.2009.12.018 Annotation The role of oxidative damage in the mechanisms of action of selected individual c-PAHs, an artificial mixture of c-PAHs and extractable organic matter (EOM) from urban air particulate matter was investigated using two cell lines (HepG2 and HEL). The response of the cell lines to the tested compounds differed substantially. The study demonstrated the potency of EOM to induce oxidative damage to DNA, lipids and proteins in HepG2 cells, but not in HEL cels. The analysis also showed that c-PAHs had less ability to cause oxidative damage. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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