Number of the records: 1
Oxidative damage by carcinogenic polycyclic aromatic hydrocarbons and organic extracts from urban air particulate matter
- 1.0340206 - ÚEM 2010 RIV NL eng J - Journal Article
Hanzalová, Kateřina - Rössner ml., Pavel - Šrám, Radim
Oxidative damage by carcinogenic polycyclic aromatic hydrocarbons and organic extracts from urban air particulate matter.
Mutation Research - Genetic Toxicology and Environmental Mutagenesis. Roč. 696, č. 2 (2010), s. 114-121. ISSN 1383-5718. E-ISSN 1879-3592
R&D Projects: GA MŠMT 2B08005; GA MŽP(CZ) SP/1B3/8/08
Institutional research plan: CEZ:AV0Z50390512
Keywords : carcinogenic polycyclic aromatic hydrocarbons * oxidative damage in vitro * extractable organic matter
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 2.938, year: 2010
The role of oxidative damage in the mechanisms of action of selected individual c-PAHs, an artificial mixture of c-PAHs and extractable organic matter (EOM) from urban air particulate matter was investigated using two cell lines (HepG2 and HEL). The response of the cell lines to the tested compounds differed substantially. The study demonstrated the potency of EOM to induce oxidative damage to DNA, lipids and proteins in HepG2 cells, but not in HEL cels. The analysis also showed that c-PAHs had less ability to cause oxidative damage.
Permanent Link: http://hdl.handle.net/11104/0183497
Number of the records: 1