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Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution
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SYSNO ASEP 0340197 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution Author(s) Rubeš, J. (CZ)
Rybář, R. (CZ)
Přinosilová, P. (CZ)
Věžník, Z. (CZ)
Chvátalová, Irena (UEM-P)
Solanský, I. (CZ)
Šrám, Radim (UEM-P) RIDSource Title Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. - : Elsevier - ISSN 0027-5107
Roč. 683, 1-2 (2010), s. 9-15Number of pages 7 s. Language eng - English Country NL - Netherlands Keywords Gene-environment interaction ; sperm chromatin structure assay ; sperm DNA damage Subject RIV DN - Health Impact of the Environment Quality R&D Projects 1QS500390506 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50390512 - UEM-P (2005-2011) AV0Z50390703 - UEM-P (2007-2013) UT WOS 000273845500002 EID SCOPUS 71549152828 DOI 10.1016/j.mrfmmm.2009.09.010 Annotation The impact of PAHs and VOCs on sperm quality in a group of city policemen in Prague during winter season (high exposure) compared to spring season (low exposure) were studied. Polymorphisms in metabolic genes (CYP1A1, EPHX1, GSTM1, GSTP1, GSTT1), folic acid metabolism genes (MTR, MTHFR) and DNA repair genes (XRCC1, XPD6, XPD23, hOGG1) were evaluated as potential modifiers of associations between air pollution exposure and changes in sperm quality. No significant differences were found in any standard semen parameters between the sampling periods except for vitality of sperms. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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