The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors

0339447 - ÚEM 2010 RIV US eng J - Journal Article
Seminatore, CH. - Polentes, J. - Ellman, D. - Kozubenko, Nataliya - Itier, V. - Tine, S. - Tritschler, L. - Brenot, M. - Guidou, E. - Blondeau, J. - Lhuillier, M. - Bugi, A. - Aubry, L. - Jendelová, Pavla - Syková, Eva - Perrier, A. L. - Finsen, B. - Onteniente, B.
The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors.
Stroke. Roč. 41, č. 1 (2010), s. 153-159. ISSN 0039-2499. E-ISSN 1524-4628
Institutional research plan: CEZ:AV0Z50390703
Keywords : brain transplantation * human embryonic stem cells * neural differentiation
Subject RIV: FH - Neurology
Impact factor: 5.756, year: 2010

We have analyzed the relative effects of the stage of differentiation and the postischemic environment on the formation of adverse structures by transplanted differently mature human embryonic stem cell-derived neural progenitors (NPs). The influence of the postischemic environment was limited to graft survival and occurrence of nonneuroectodermal structures after transplantation of very immature NPs. Both effects were lost with differentiation. We identified a particular stage of differentiation characterized in vitro by a rebound of proliferative aktivity that produced highly proliferative grafts susceptible to threaten surrounding host tissues. The effects of the ischemic environment on the formation of teratoma by transplanted NPs are limited to early differentiation stages that will likely not be used for stem cell therapy. In contrast, hyperproliferation observed at later stages of differentiation corresponds to an intrinsic activity that should be monitored to avoid tumorigenesis in vivo.
Permanent Link: http://hdl.handle.net/11104/0182969