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Exhaled Leukotrienes and Bronchial Responsiveness to Methacholine in Patients with Seasonal Allergic Rhinitis
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SYSNO ASEP 0338859 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Exhaled Leukotrienes and Bronchial Responsiveness to Methacholine in Patients with Seasonal Allergic Rhinitis Author(s) Čáp, P. (CZ)
Malý, Marek (UIVT-O) RID, SAI
Pehal, F. (CZ)
Pelikán, Z. (CZ)Source Title Annals of Allergy Asthma & Immunology - ISSN 1081-1206
Roč. 102, č. 2 (2009), s. 103-109Number of pages 7 s. Language eng - English Country US - United States Keywords allergic rhinitis ; asthma ; breath condensate ; leukotrienes ; gas chromatography ; mass spectrometry analysis Subject RIV FN - Epidemiology, Contagious Diseases ; Clinical Immunology CEZ AV0Z10300504 - UIVT-O (2005-2011) UT WOS 000263084000004 DOI 10.1016/S1081-1206(10)60238-4 Annotation Aim of the study was to investigate the relationship between the postseasonal increase in the concentration of leukotriene (LT) B4 and LTE4 in exhaled breath condensate (EBC) and bronchial responsiveness to methacholine (BRM) in patients with seasonal allergic rhinitis (SAR). In 28 patients with SAR and 50 healthy study patients, the leukotrienes were measured during and after the pollen season by gas chromatography/mass spectrometry. Following seasonal and postseasonal median values were measured in patients with SAR in comparison with control patients: LTB4: 131 and 90 pg/mL vs 80 and 79 pg/mL, P < .001 and P = .03, respectively; LTE4: 122 and 86 pg/mL vs 76 and 74 pg/mL, P < .001and P = .02, respectively. Five months after the pollen season, the concentrations of LTB4 and LTE4 decreased with respect to their seasonal values (P < .001). The seasonal and postseasonal increases in LTB4 and LTE4 concentrations in EBC correlated significantly with the later increase in BRM. Workplace Institute of Computer Science Contact Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Year of Publishing 2010
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