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Exhaled Leukotrienes and Bronchial Responsiveness to Methacholine in Patients with Seasonal Allergic Rhinitis

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    SYSNO ASEP0338859
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleExhaled Leukotrienes and Bronchial Responsiveness to Methacholine in Patients with Seasonal Allergic Rhinitis
    Author(s) Čáp, P. (CZ)
    Malý, Marek (UIVT-O) RID, SAI
    Pehal, F. (CZ)
    Pelikán, Z. (CZ)
    Source TitleAnnals of Allergy Asthma & Immunology - ISSN 1081-1206
    Roč. 102, č. 2 (2009), s. 103-109
    Number of pages7 s.
    Languageeng - English
    CountryUS - United States
    Keywordsallergic rhinitis ; asthma ; breath condensate ; leukotrienes ; gas chromatography ; mass spectrometry analysis
    Subject RIVFN - Epidemiology, Contagious Diseases ; Clinical Immunology
    CEZAV0Z10300504 - UIVT-O (2005-2011)
    UT WOS000263084000004
    DOI10.1016/S1081-1206(10)60238-4
    AnnotationAim of the study was to investigate the relationship between the postseasonal increase in the concentration of leukotriene (LT) B4 and LTE4 in exhaled breath condensate (EBC) and bronchial responsiveness to methacholine (BRM) in patients with seasonal allergic rhinitis (SAR). In 28 patients with SAR and 50 healthy study patients, the leukotrienes were measured during and after the pollen season by gas chromatography/mass spectrometry. Following seasonal and postseasonal median values were measured in patients with SAR in comparison with control patients: LTB4: 131 and 90 pg/mL vs 80 and 79 pg/mL, P < .001 and P = .03, respectively; LTE4: 122 and 86 pg/mL vs 76 and 74 pg/mL, P < .001and P = .02, respectively. Five months after the pollen season, the concentrations of LTB4 and LTE4 decreased with respect to their seasonal values (P < .001). The seasonal and postseasonal increases in LTB4 and LTE4 concentrations in EBC correlated significantly with the later increase in BRM.
    WorkplaceInstitute of Computer Science
    ContactTereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800
    Year of Publishing2010
Number of the records: 1  

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