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Polyvinyl chloride catheters with repressed migration of plasticizers
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SYSNO ASEP 0337033 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Polyvinyl chloride catheters with repressed migration of plasticizers Author(s) Sedláček, T. (CZ)
Polášková, M. (CZ)
Kašpárková, V. (CZ)
Filip, Petr (UH-J) ORCID, RID, SAI
Sáha, P. (CZ)Number of authors 5 Source Title Proceedings of the Polymer Processing Society Europe/Africa Regional Meeting. - Larnaca : Polymer Processing Society, 2009 Pages s. 243 Number of pages 3 s. Action Polymer Processing Society Europe/Africa Regional Meeting Event date 18.10.2009-21.10.2009 VEvent location Larnaca Country GR - Greece Event type WRD Language eng - English Country CZ - Czech Republic Keywords Polyvinyl chloride ; catheter ; repressed migration of plasticizers Subject RIV BK - Fluid Dynamics CEZ AV0Z20600510 - UH-J (2005-2011) Annotation Impart flexibility and desired softness of polyvinylchloride (PVC) – one of the most widely used polymeric materials for medical device production – is achieved by addition of appropriate amount of plasticizer, usually di(2-ethylhexyl phthalate) (DEHP), into polymer matrix. DEHP is not chemically bonded to PVC and migrates to the surrounding media such as saliva, blood, plasma, or serum resulting in several toxic effects. Migration of DEHP can be significantly suppressed by embedding PVC into another polymer preventing its direct contact with surrounding liquid media. Coextruded TPU-PVC-TPU catheters were prepared with various thicknesses of TPU layers to evaluate its repressing effect on DEHP releasing. Releasing kinetic of DEPH from both three layered catheters and PVC catheters into the acetonitrile was observed in various time intervals and determined using reverse-phase liquid chromatographic technique. Workplace Institute of Hydrodynamics Contact Soňa Hnilicová, hnilicova@ih.cas.cz, Tel.: 233 109 003 Year of Publishing 2010
Number of the records: 1