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Evaluation of Antimicrobial and Anti-Inflammatory Activities of Seed Extracts from Six Nigella Species
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SYSNO ASEP 0335914 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Evaluation of Antimicrobial and Anti-Inflammatory Activities of Seed Extracts from Six Nigella Species Author(s) Landa, Přemysl (UEB-Q) RID, ORCID
Maršík, Petr (UEB-Q) RID, ORCID
Havlík, J. (CZ)
Klouček, P. (CZ)
Vaněk, Tomáš (UEB-Q) RID, ORCID
Kokoška, L. (CZ)Source Title Journal of Medicinal Food - ISSN 1096-620X
Roč. 12, č. 2 (2009), s. 408-415Number of pages 8 s. Language eng - English Country US - United States Keywords antimicrobial activity ; cyclooxygenase-1 ; cyclooxygenase-2 Subject RIV EI - Biotechnology ; Bionics R&D Projects ME08070 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GP525/09/P528 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000266279000023 DOI 10.1089/jmf.2007.0600 Annotation Seed extracts from six species of the genus Nigella (Family Ranunculaceae)-Nigella arvensis, Nigella damascena, Nigella hispanica, Nigella nigellastrum, Nigella orientalis, and Nigella sativa-obtained by successive extraction with n-hexane, chloroform, and methanol, were tested for their antimicrobial activity against 10 strains of pathogenic bacteria and yeast using the microdilution method as well as for anti-inflammatory properties by in vitro cyclooxygenase (COX)-1 and COX-2 assay. Chemical characterization of active extracts was carried out including free and fixed fatty acid analysis. Comparison of antimicrobial activity showed that N. arvensis chloroform extract was the most potent among all species tested, inhibiting Gram-positive bacterial and yeast strains with minimum inhibitory concentration (MIC) values ranging from 0.25 to 1 mg/mL. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2010
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