Comparison of cell death-inducing effect of novel taxane SB-T-1216 and paclitaxel in breast cancer cells
1.
SYSNO ASEP
0333896
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Článek ve WOS
Title
Comparison of cell death-inducing effect of novel taxane SB-T-1216 and paclitaxel in breast cancer cells
Author(s)
Kovář, J. (CZ) Ehrlichová, M. (CZ) Šmejkalová, Barbora (UMG-J) Zanardi, I. (US) Ojima, I. (US) Gut, I. (CZ)
Number of authors
6
Source Title
Anticancer Research. - : International Institute of Anticancer Research
- ISSN 0250-7005
Roč. 29, č. 8 (2009), s. 2951-2960
Number of pages
10 s.
Language
eng - English
Country
GR - Greece
Keywords
Cell death ; taxane SB-T-1216 ; paclitaxel
Subject RIV
EB - Genetics ; Molecular Biology
R&D Projects
GD204/05/H023 GA ČR - Czech Science Foundation (CSF)
CEZ
AV0Z50520514 - UMG-J (2005-2011)
UT WOS
000268846800011
Annotation
Cell death induced by both paclitaxel and novel taxane SB-T-1216 in breast cancer cells is associated with caspase activation and with the formation of interphase microtubule bundles. Novel taxane SB-T-1216, but not paclitaxel, seems to be capable of inducing cell death without the accumulation of cells in the G(2)/M phase.
