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Industasis, a promotion of tumor formation by nontumorigenic stray cells
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SYSNO ASEP 0333751 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Industasis, a promotion of tumor formation by nontumorigenic stray cells Author(s) Pajer, Petr (UMG-J)
Karafiát, Vít (UMG-J)
Pečenka, Vladimír (UMG-J)
Průková, Dana (UMG-J)
Dudlová, J. (CZ)
Plachý, Jiří (UMG-J) RID
Kašparová, P. (CZ)
Dvořák, Michal (UMG-J) RIDNumber of authors 8 Source Title Cancer Research. - : American Association for Cancer Research - ISSN 0008-5472
Roč. 69, č. 11 (2009), s. 4605-4612Number of pages 8 s. Language eng - English Country US - United States Keywords tumor promotion ; lung tumors ; Fyn-related kinase Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA204/06/1728 GA ČR - Czech Science Foundation (CSF) LC06061 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) IAA500520608 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000266755000010 DOI 10.1158/0008-5472.CAN-08-4636 Annotation We have demonstrated that transient presence of non-tumorigenic stray cells in tissues of experimental animals containing cells with a sub-critical set of genetic mutations can act as a tumor-promoting stimulus. To induce somatic mutations in all chicken tissues we used MAV-2 retroviral insertion system almost exclusively generating nephroblastomas. MAV-2 mutagenized animals inoculated with non-malignant cells developed early clonal lung tumors prior to nephroblastomas. Importantly, injected cells did not become a component of resultant tumors. Lung tumors displayed specific mutational signature characterized by insertion of MAV-2 provirus into frk promoter resulting in over-expression of gene frk. In contrast, plag1, foxP1 and twist genes were most often mutagenized in nephroblastomas. We propose the mechanism termed industasis, a promotion of fully malignant phenotype of incipient tumor cell by stray cells, and hypothesize that it might be a cause of human multiple primary tumors. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2010
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