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Genetical genomic determinants of alcohol consumption in rats and humans
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SYSNO ASEP 0333701 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genetical genomic determinants of alcohol consumption in rats and humans Title Geneticko genomické determinanty konzumace alkoholu u potkanů a u lidí Author(s) Tabakoff, B. (US)
Saba, L. (US)
Printz, M. (US)
Flodman, P. (US)
Hodgkinson, C. (US)
Goldman, D. (US)
Koob, G. (US)
Richardson, H.N. (US)
Kechris, K. (US)
Bell, R.L. (US)
Hübner, N. (DE)
Heinig, M. (DE)
Pravenec, Michal (FGU-C) RID, ORCID
Mangion, J. (GB)
Legault, L. (CA)
Dongier, M. (CA)
Conigrave, K.M. (AU)
Whitfield, J.B. (AU)
Saunders, J. (AU)
Grant, B. (US)
Hoffman, P.L. (US)Source Title BMC BIOLOGY. - : BioMed Central
Roč. 7, - (2009), s. 70-70Number of pages 23 s. Language eng - English Country GB - United Kingdom Keywords alcohol consumption ; rat ; gene expression profiles Subject RIV EB - Genetics ; Molecular Biology R&D Projects 1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000271839600001 DOI 10.1186/1741-7007-7-70 Annotation In the HXB/BXH recombinant inbred (RI) rats, correlation analysis of brain gene expression levels with alcohol consumption in a two-bottle choice paradigm generated a list of candidate genes and signaling pathways. In the human populations, polymorphisms in genes associated with GABA synthesis and GABA receptors, as well as genes related to dopaminergic transmission, were associated with alcohol consumption.The results suggest cross-species similarities in pathways that influence predisposition to consume alcohol by rats and humans. Our results also suggest that different genetic factors predispose alcohol dependence versus the phenotype of alcohol consumption Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2010
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