A study of HIV-1 genetic diversity in the Czech Republic: 1986-2007

0333601 - ÚMG 2010 RIV CZ eng J - Journal Article
Linka, M. - Brůčková, M. - Malý, M. - Vandasová, J. - Stanková, M. - Reiniš, Milan
A study of HIV-1 genetic diversity in the Czech Republic: 1986-2007.
Central European Journal of Public Health. Roč. 16, č. 4 (2009), s. 175-177. ISSN 1210-7778. E-ISSN 1803-1048
Grant - others:MZd ČR(CZ) NR7843
Institutional research plan: CEZ:AV0Z50520514
Keywords : HIV-1 subtyping * non-B subtypes * molecular epidemiology
Subject RIV: EB - Genetics ; Molecular Biology

The global HIV/AIDS epidemic consists of a number of regional epidemics caused by different HIV-1 subtypes prevailing in different regions. We have studied changes in genetic diversity of HIV-1 strains isolated in the Czech Republic (CR) over a more than twenty-year period (1986–2007). HIV-1 strains isolated in CR from 1986 to 2007 were subtyped by pol gene sequencing followed by phylogenetic analysis. A wide range of HIV-1 subtypes were found, with subtype B, into which 76.6 % of 534 HIV-1 isolates were classified, being predominant during the whole study period. An increasing number of non-B subtypes A1, C, D, F1, G and some recombinant forms (CRF 01_AE, CRF 02_AG and CRF 06_cpx) were identified after 1990. The absolute predominance of subtype B among HIV-1 strains in CR ended in 1991 when different non-B subtypes had been introduced into the country. The East-West migration is responsible for the introduction of HIV-1 subtypes prevalent in Eastern European and some Asian countries.
Permanent Link: http://hdl.handle.net/11104/0178546