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Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs
- 1.0332328 - BFÚ 2010 RIV DE eng J - Journal Article
Hofmanová, Jiřina - Vaculová, Alena - Koubková, Zuzana - Hýžďalová, Martina - Kozubík, Alois
Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs.
Molecular Nutrition & Food Research. Roč. 53, č. 1 (2009), S102-S113. ISSN 1613-4125. E-ISSN 1613-4133
R&D Projects: GA ČR(CZ) GA524/07/1178; GA AV ČR(CZ) 1QS500040507; GA ČR(CZ) GA301/07/1557
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : apoptosis * butyrate * cell differentiation
Subject RIV: BO - Biophysics
Impact factor: 4.356, year: 2009
Comparing human colon epithelial cell lines of fetal (FHC) and adenocarcinoma (HT-29, HCT-116) origin, we detected significant differences in proliferation, differentiation, and apoptotic response to the treatment of sodium butyrate (NaBt), arachidonic or docosahexaenoic acids, and their combination. Our results support the concept of modulation of NaBt effects by polyunsaturated fatty acids, especially of omega-3 type, in colonic cells in vitro with diverse impact in cell lines derived from normal or neoplastic epithelium.
Permanent Link: http://hdl.handle.net/11104/0177620
Number of the records: 1