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The Fischer 344 rat as a model of presbycusis
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SYSNO ASEP 0332199 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The Fischer 344 rat as a model of presbycusis Author(s) Syka, Josef (UEM-P) RID Source Title Hearing Research. - : Elsevier - ISSN 0378-5955
Roč. 264, 1-2 (2010), s. 70-78Number of pages 9 s. Language eng - English Country NL - Netherlands Keywords Rat ; Fischer 344 ; Presbycusis Subject RIV FH - Neurology R&D Projects GA309/07/1336 GA ČR - Czech Science Foundation (CSF) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000278694100010 DOI 10.1016/j.heares.2009.11.003 Annotation Pronounced hearing loss at the end of the second year, the rapid deterioration of distortion product otoacoustic emissions with the majority of outer hair cells being present and morphologically intact, produced apparently by the disruption of prestin, and deterioration of acoustical signal processing within central auditory system supports the idea that the Fischer 344 rat strain may serve as a suitable model for studying the mechanisms of presbycusis, its prevention and treatment. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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